Furin - Wikipedia
WEBFurin is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. [13] This protease is also thought to play a role in tumor progression. [ 7 ]
Furin at the cutting edge: From protein traffic to ... - Nature
WEBOct 1, 2002 · Many pathogenic viruses, including avian influenza virus, HIV-1 and measles virus, express envelope glycoproteins that require processing at consensus furin sites to form mature, fusogenic...
Structure of a cleavage-independent HIV Env recapitulates the ...
WEBMay 16, 2018 · Furin cleavage of the HIV envelope glycoprotein is an essential step for cell entry that enables formation of well-folded, native-like glycosylated trimers, releases constraints on the...
HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin
WEBJan 25, 2019 · We showed that wild-type (WT) PAR1, but not its R46A mutant, lowers viral infectivity by inhibiting the ability of Furin to process the HIV-1 gp160 into gp120/gp41 .
Furin‐mediated protein processing in infectious diseases and cancer
WEBAug 5, 2019 · In this review, we describe the physiological and pathophysiological substrates of furin and discuss how dysregulation of a simple proteolytic cleavage event may promote infectious diseases and cancer. One major focus is the role of furin in viral glycoprotein maturation and pathogenicity.
Furin‐mediated protein processing in infectious diseases and …
WEBAug 5, 2019 · PAR1 as well as GBP2 and GBP5 reduces HIV particle infectivity by inhibiting furin-mediated Env processing. Human immunodeficiency virus (HIV) particles containing functional mature envelope (Env) glycoproteins fuse with the plasma membrane of the target cell to release the capsid core into the host cell cytoplasm.
FURIN AT THE CUTTING EDGE: FROM PROTEIN TRAFFIC TO …
WEBFurin cleaves HIV-1 gp160 at the carboxy-terminal side of the consensus sequence –Arg–Glu–Lys–Arg– ↓. The P3 glutamate in this cleavage site reduces the efficiency of furin processing, and the conservation of this residue in several HIV isolates has raised doubts about furin's involvement in gp160 processing 136 .
Processing and routage of HIV glycoproteins by furin to the cell ...
WEBFurin. Proteolytic activation of HIV-1 and HIV-2 envelope glycoprotein precursors (gp160 and gp140, respectively) occurs at the carboxyl side of a consensus motif consisting of the highly basic amino acid sequence. We have shown previously (Hallenberger et al., 1997) and confirmed in this report, that furi ….
Inhibition of Infectious HIV-1 Production by Rerouting the Cellular ...
WEBJun 29, 2023 · Here, we show that Serpin B8, an endogenous furin inhibitor, can inhibit HIV-1 Env maturation and efficiently reduce infectious HIV-1 production when rerouted to the secretory pathway. The results of our study not only provide important insights into the biology of Serpins, but also show how protein engineering of an endogenous furin inhibitor ...
A perspective on the applications of furin inhibitors for the …
WEBJan 15, 2022 · Furin is a subtilisin-like proprotein convertase with diverse cellular functions. Emerging evidence suggests that furin plays a critical role in the activation and/or infectivity of SARS-CoV-2. In this perspective, we discuss the potential role of furin in the entry SARS-CoV-2 into host cells.