Mechanisms of Neuronal Dysfunction and Degeneration in Multiple Sclerosis
WEBAbstract. Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Due to its high prevalence, MS is the leading cause of non-traumatic neurological disability in young adults in the United States and Europe.
Mechanisms of Neurodegeneration and Axonal Dysfunction in …
WEBFeb 20, 2019 · Multiple Sclerosis (MS) is a major cause of neurological disability, which increases predominantly during disease progression as a result of cortical and grey matter structures involvement.
Neurodegeneration in multiple sclerosis - PMC - National Center …
WEBAug 10, 2022 · Abstract. Axonal loss in multiple sclerosis (MS) is a key component of disease progression and permanent neurologic disability. MS is a heterogeneous demyelinating and neurodegenerative disease of the central nervous system (CNS) with varying presentation, disease courses, and prognosis.
The neuropathobiology of multiple sclerosis - Nature
WEBMay 24, 2024 · Understanding neuronal deregulation, and the underlying neuronal actuators, key molecular regulators and pathways that define vulnerability to inflammation and autonomously drive...
Mechanisms of neurodegeneration and axonal dysfunction in multiple …
WEBMar 18, 2014 · Neuronal and axonal degeneration in multiple sclerosis (MS) is a slow process initiated by acute lymphocytic inflammation, and subsequently driven by chronically smouldering, diffuse...
Brain atrophy in multiple sclerosis: mechanisms, clinical …
WEBAug 10, 2019 · Brain atrophy, the gradual loss of brain volume, is quite extensive in MS, nearly 0.5–1.35% per year, far off the limits of normal aging [5, 6]. It arises early in the course of the disease, accelerates with disease progression [7, 8, 9, 10, 11, 12] but is attenuated by disease-modifying drugs [13].
Neurodegeneration and demyelination in multiple sclerosis - Cell …
WEBJun 17, 2024 · Progressive multiple sclerosis (PMS) is a neurodegenerative condition with chronic inflammation and glial cell pathology. In this review, Garton et al. discuss immune-glia interactions in PMS, highlighting potential therapeutic targets for PMS and other neurodegenerative diseases.
Chronic Demyelination and Axonal Degeneration in Multiple Sclerosis ...
WEBApr 9, 2021 · Purpose of review: Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS). Inflammatory attacks in MS lead to both demyelination and axonal damage. However, due to incomplete remyelination most MS lesions remain chronically demyelinated.
Mechanisms of neurodegeneration and axonal dysfunction in multiple …
WEBAbstract. Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and imposes major burdens on young lives.
Neurodegeneration in multiple sclerosis - PubMed
WEBAxonal loss in multiple sclerosis (MS) is a key component of disease progression and permanent neurologic disability. MS is a heterogeneous demyelinating and neurodegenerative disease of the central nervous system (CNS) with varying presentation, disease courses, and prognosis.