PEG-Lipids: Quantitative Study of Unimers and Aggregates …
WEBJul 7, 2023 · Here, we study the dynamics of poly(ethylene glycol)-lipid (PEG-Lipid) conjugates aiming at a better understanding of their molecular properties and aggregation behavior in solution. Those PEG-Lipids are used as components of …
PEGylated Lipid Nanoparticle Formulations: Immunological Safety …
WEBAs one of their key constituents, polyethylene glycol (PEG)–lipid conjugates are important in defining LNP physicochemical characteristics and biological activity. PEGylation has proven particularly efficient in conferring longer systemic circulation of LNPs, thus greatly improving their pharmacokinetics and efficiency.
What are PEG lipids? - BroadPharm
WEBOct 6, 2021 · PEG lipids, also known as PEGylated lipids are a class of PEG derivatives that are attached to a lipid moiety such as DMG or DSPE. PEG lipid has been used extensively to improve circulation times for liposome encapsulated (LNP) drugs and reduce non-specific uptakes.
Understanding the Role and Impact of Poly (Ethylene Glycol) (PEG) …
WEBPoly (ethylene glycol) (PEG) is a non-ionic polyether compound and has been widely used in common applications in cosmetics, food products, and pharmaceuticals for its excellent properties as a solvent, plasticizer, surfactant, base, and …
PEGylation as a strategy for improving nanoparticle-based drug …
WEBApr 1, 2016 · Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a commonly used approach for improving the efficiency of drug and gene delivery to target cells and tissues.
Cleavable PEGylation: a strategy for overcoming the “PEG …
WEBOct 25, 2017 · To achieve successful drug delivery for effective treatment, the crucial issue associated with the use of PEG-lipids, that is, “PEG dilemma” must be addressed. In this paper, we introduced the development and application of nanocarriers with cleavable PEGylation, and discussed various strategies for overcoming the PEG dilemma.
The ultimate guide for PEGylated lipid nanoparticles - CAS
WEBMay 26, 2023 · Polyethylene glycol (PEG) is a flexible, non-toxic, hydrophilic polymer with a broad range of applications, from personal care products to pharmaceutical formulations. PEG-lipids have been widely used in pharmaceutical lipid nanoparticle (LNP) formulations for anti-cancer medications such as doxorubicin, irinotecan, and cisplatin, as well as ...
Lipid nanoparticles for mRNA delivery | Nature Reviews Materials
WEBAug 10, 2021 · Lipid nanoparticle–siRNA formulations containing PEG 2000-DMG have shorter circulation times and higher delivery efficacy in vivo than formulations containing PEG 2000-DSG 129.
Lipid nanoparticles with PEG-variant surface modifications …
WEBOct 13, 2023 · Here, Gautam et al., show that surface modifications of lipid nanoparticles with PEG variants alters their cellular tropism allowing gene editing in diverse retinal cell types in mice.
Recent development of poly(ethylene glycol)-cholesterol conjugates as ...
WEBJul 20, 2014 · Poly (ethylene glycol)-cholesterol (PEG-Chol) conjugates are composed of "hydrophilically-flexible" PEG and "hydrophobically-rigid" Chol molecules. PEG-Chol conjugates are capable of forming micelles through molecular self-assembly and they are also used extensively for the PEGylation of drug delivery systems (DDS).