Pegylated recombinant human epidermal growth factor (rhEGF) …
WEBRecombinant human epidermal growth factor (rhEGF) was conjugated with polyethylene glycol (PEG) to improve its physical stability during microencapsulation in biodegradable poly (lactic-co-glycolic acid) microspheres. rhEGF was conjugated with N-hydroxysuccimide (NHS)-derivatized methoxy-PEG (mPEG) of MW …
Effect of molecular size of PEGylated recombinant human …
WEBThe purpose of this study was to investigate the effect of size of polyethylene glycol (PEG) conjugated to recombinant human epidermal growth factor (rhEGF) on its stability in skin wound tissue and in vitro biological activity to find the desirable conjugate as topical therapeutic agent for wound h …
Pegylated recombinant human epidermal growth factor (rhEGF) …
WEBRecombinant human epidermal growth factor (rhEGF) was conjugated with polyethylene glycol (PEG) to improve its physical stability during microencapsulation in biodegradable poly (lactic-co-glycolic acid) microspheres. rhEGF was conjugated with N-hydroxysuccimide (NHS)-derivatized methoxy-PEG (mPEG) of MW …
EGF, a veteran of wound healing: highlights on its mode of action ...
WEBPEG-coated liposomes enhance encapsulation efficiency and increase gastro-intestinal stability and absorption of rhEGF (Li et al. 2003). PEG conjugation (PEGylation) of rhEGF provided better physical stability during the emulsification process and improved the release behavior of rhEGF from PLGA microspheres (Kim et al. 2002 ).
Screening for stability and compatibility conditions of recombinant ...
WEBAug 16, 2013 — Polymers like poly (ethylene glycol) (PEG) and polysorbates increased methionine oxidation. The rhEGF oxidation and deamidation were the most common degradation pathways. This research identified critical solution factors to be considered for the development of a successful rhEGF parenteral formulation. Graphical abstract.
Effect of Molecular Size of PEGylated Recombinant Human Epidermal ...
WEBOct 7, 2008 — This study suggests that the high molecular weight PEG at N-terminus of rhEGF would give a satisfactory stabilizing effect and thus may improve therapeutic efficacy in clinical use. Keywords: recombinant human epidermal growth factor , PEGylation , protein stability , biological activity , wound healing
Effect of molecular size of PEGylated recombinant human …
WEBThis study suggests that the high molecular weight PEG at N-terminus of rhEGF would give a satisfactory stabilizing effect and thus may improve therapeutic efficacy in clinical use.
Polyethylene glycol-coated liposomes for oral delivery of …
WEBJul 1, 2003 — Polyethylene glycol (PEG)-coated liposomes containing rhEGF was prepared and evaluated for their stability and permeability in Caco-2 cells. In the animal study, we also determined plasma...
N-terminal PEGylation of rhEGF with mPEGButyrALD (a) and …
WEBCovalent attachment of poly(ethylene) glycol (PEG) groups to proteins, a process commonly called PEGylation, is often used to improve the performance of a protein in vivo.
Pegylated recombinant human epidermal growth factor (rhEGF…
WEBJun 1, 2002 — Recombinant human epidermal growth factor (rhEGF) was conjugated with polyethylene glycol (PEG) to improve its physical stability during microencapsulation in biodegradable poly (lactic-co-glycolic acid) microspheres. rhEGF was conjugated with N -hydroxysuccimide (NHS)-derivatized methoxy-PEG (mPEG) of MW 2000 and 5000 under various reaction con...
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