Blakesburg is a city in Wapello County, Iowa, United States. The population was 274 at the 2020 census. Blakesburg was laid out in 1852. It was named for one of its founders, Theophilus Blake. According to the United States Census Bureau, the city has a total area of 0.27 square miles, all land. The ZIP code for Blakesburg is 52536.