Colón is a province of Panama. The capital is the city of Colón. It covers an area of 4,575.5 km², and the population is 281,956. This province has traditionally been focused on commerce, but also has natural resources that are being developed as a tourist attraction, such as coral reefs and rainforests. During the Spanish colonial period, the Colon region of P…Colón is a province of Panama. The capital is the city of Colón. It covers an area of 4,575.5 km², and the population is 281,956. This province has traditionally been focused on commerce, but also has natural resources that are being developed as a tourist attraction, such as coral reefs and rainforests. During the Spanish colonial period, the Colon region of Panama was the center of trade, commerce, and overall economy for the Spanish. They imported many black African slaves to this area to work in Panama and to ship to other Spaniard colonies.