Harrisburg is a village in Franklin and Pickaway counties in the U.S. state of Ohio. The population was 315 at the 2020 census. Harrisburg was founded in 1836 by Joseph Chenowith, and surveyed and platted by Frederick Cole. Prior to the laying out of the village, the area was known as Darby Cross Roads. The present name is after Harrisburg, Penns…Harrisburg is a village in Franklin and Pickaway counties in the U.S. state of Ohio. The population was 315 at the 2020 census. Harrisburg was founded in 1836 by Joseph Chenowith, and surveyed and platted by Frederick Cole. Prior to the laying out of the village, the area was known as Darby Cross Roads. The present name is after Harrisburg, Pennsylvania.