Tuskegee is a city in Macon County, Alabama, United States. General Thomas Simpson Woodward, a Creek War veteran under Andrew Ja…Tuskegee is a city in Macon County, Alabama, United States. General Thomas Simpson Woodward, a Creek War veteran under Andrew Jackson, laid out the city and founded it in 1833. It became the county seat in the same year and it was incorporated on February 13, 1843. It is the most populous city in Macon County. The population was 9,395 at the 2020 census, and was estimated to be 8,765 in 2023.
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