Anthony Santander hit a game-ending two-run homer with two outs in the ninth inning, his 42nd longball of the season, and the Baltimore Orioles moved closer to a postseason birth with a 5-3 victory over the San Francisco Giants on Thursday.

Anthony Santander snapped the Orioles' losing streak with a walk-off, 2-run home run against the Giants on Thursday, adding to his career year at the plate.

The San Francisco Giants almost certainly won't be in the postseason, but they are off to a good start to a long road trip.

Mike Yastrzemski homered on the game’s first pitch, Michael Conforto also hit a solo shot and the San Francisco Giants beat the sinking Baltimore Orioles 5-3