There was a clinically meaningful reduction in proteinuria with iptacopan (Fabhalta), and a confirmed clinical benefit of ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3 ...

Researchers have discovered that SARS-CoV-2 hijacks three important host proteins that dampen the activity of the complement system ... through three different pathways, complement facilitates ...