They are non-integrating vectors so expression in dividing cells is progressively lost. First generation vectors may be suitable for applications where transient, high level activity is sufficient, ...

They can infect both dividing and non-dividing cells and provide high levels of gene expression. However, adenoviral vectors can trigger strong immune responses, limiting their long-term efficacy.

lentivirus-based vectors, derived from the HIV-1 retrovirus, are of growing interest in gene and cell therapy, particularly in immuno-oncology, due to their ability to infect dividing and ...