which is associated with higher levels of expression of the glucocorticoid receptor gene. These epigenetic changes in DNA methylation and histone acetylation occurred during the 1st week of life ...

More information: Aishwarya Iyer-Bierhoff et al, Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling, iScience (2024). DOI: 10.1016/j.isci.

For instance, histone acetylation reduces the positive charge of the histone proteins, thereby reducing their affinity for DNA and causing the chromatin to open (Figure 2). This in turn permits ...