Such probes are sensitive, even to single base differences in target DNA. Freed from the constraint of needing hydrogen bonding to achieve rapid, high-fidelity DNA synthesis, one may be able to ...

First, a so-called initiator protein unwinds a short stretch of the DNA double helix. Then, a protein known as helicase attaches to and breaks apart the hydrogen bonds between the bases on the DNA ...

It's not hydrogen bonds don't have a role to play. They're still the ones responsible for sorting base pairs and making sure they're all in the right sequence. But, it's water that holding the DNA ...

Chemical structure of guanine, showing its double-ring purine structure and the functional groups involved in hydrogen bonding with cytosine. (Image: Public Domain) Guanine has the chemical formula ...