In contrast, TLRs 3, 7, 8, and 9 are situated in the membranes of endosomes and lysosomes; the extracellular domain of the receptor and its ligand-binding site project into the interior of these ...
Alon Kahana, MD, PhD, discusses the role of interleukin-6 in thyroid eye disease and the potential of tourmaline Bio's IL-6 ...
PELSA is a sensitive, versatile method for identifying ligand-binding proteins and sites in native systems without requiring ...
Recent advancements in understanding the molecular basis of the prostaglandin D2 receptor (DP2) have significant implications ...
The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?
GPR6 is an orphan G protein-coupled receptor primarily expressed in the ... a lipid-like molecule occupying the orthosteric ligand-binding pocket. A cryo-EM structure of the fully active GPR6 ...
Researchers have tested strategies to combine riboswitches—RNA motifs that change conformation in response to binding another molecule—with these aptamers to create biosensors that fluoresce only when ...
In a significant advancement for cancer research, a team of scientists from Max Planck Institute for Biology Tübingen, ...
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