The discovery of lysosomes led to many new questions. The most critical question was: what was the physiological function of this "bag" of enzymes? The Function of Lysosomes One of the definitive ...

Think back to that basic biology class you took in high school. You probably learned about organelles, those little "organs" ...

Furthermore, the team identified the signalling pathway by which the protein INPP4B drives the movement of lysosomes to the ...

Both lysosomes and autophagy are tightly linked with longevity and healthspan, the length of time that a person is healthy, ...

More information: Shane K. B. Taylor et al, The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans, Proceedings of the National ...

Within these tissues, MANF was present in structures known as lysosomes which are associated ... helping them function better for longer. “Although our research focused on worms, the findings ...

McMaster University researchers have discovered a previously unknown cell-protecting function of a protein ... MANF was present in structures known as lysosomes which are associated with lifespan ...

Lipids Open the Door. Microglial cells treated with unlipidated (top) or lipidated (bottom) ApoE (yellow) along with fluorescently tagged Aβ (green). Lipidated ApoE was more readily internalized and ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Figure 1. Entosis promotes cell competition. (A) Entosis ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...

Researchers have discovered a previously unknown cell-protecting function of a protein ... MANF was present in structures known as lysosomes which are associated with lifespan and protein ...