Some gain-of-function phenotypes of mutant p53 may result from the loss of multiple functions rather than novel functions. This aggregation effect, alongside impaired tetramer formation ...

The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro. The ability of mutant p53 to bind ...

They reported an RNA aptamer-based PROTAC degrader capable of targeting and degrading the p53-R175H mutant previously. However, the serum instability limits its clinical translation. In this study ...

Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a new way in which RAS genes, ...

Presentation Details: Title: CLSP-1025, a novel bispecific T cell engager targeting a p53 R175H mutant peptide presented by HLA-A*02:01 Presentation Type: Poster Abstract Number: 1061 Date and ...

P53 Overexpression and mutation seen in children >3 years and young adults; possible independent prognostic factor Less common in elderly patients EGFR/EGFRvIII Less common in pediatric patients ...

University of Virginia Health System, Department of Pathology, Division of Neuropathology, Box 800214, Charlottesville, VA 22908-0214, USA (T. D. Bourne). University of Virginia Health System ...

Please verify your email address. The iconic band of brothers is back for another instalment, with Teenage Mutant Ninja Turtles: Mutants Unleashed kicking off another chapter in the lives of Leo ...

AMPLIFY-7P Phase 2 randomized study anticipated to complete enrollment in Q4 2024; formal interim analysis of disease-free survival ("DFS") expected in H1 2025Poster presentation at the Society for Im ...

Please verify your email address. If you remove Splintered Fate from the ever-growing shadow of Hades, you might just find what Super Evil Megacorp clearly tried hard to create: a relentlessly ...

IDW recently relaunched their flagship Teenage Mutant Ninja Turtles comic with a star-studded creative team, including new series writer Jason Aaron and a rotating team of artists. Now IGN can ...

“Based on proof-of-concept data demonstrating the ability of rezatapopt to selectively reactivate p53 in locally advanced/metastatic solid tumor patients with a TP53 Y220C mutation, we believe that ...