The pair had helped identify a still-unnamed disease, which they had tied to a particular gene and to a particular somatic mutation—a genetic change that had not been passed down from a parent and was ...

The result is a state called “somatic mosaicism,” in which two or more groups of cells in the same body possess different genetic compositions. In recent years, the discovery of conditions such as ...

By about 1900 the observations of Hertwig, Fol, and others were brought together to make the now-familiar picture: a single ...

New work by Columbia researchers has turned a textbook principle of genetics on its head and revealed why some people who ...

How do mutations happen, and how do they influence the future of a species? Molecules of sickle-cell hemoglobin stick to one another, forming rigid rods. These rods cause a person's red blood ...

Loss of the Y chromosome (LOY) in men, a dynamic mutation linked to aging, impairs immune function and increases risks of ...

Researchers at Columbia University reveal how monoallelic expression (MAE) shapes genetic disease outcomes. By favoring one ...

A sperm cell and an egg cell each contain half the ... If one of a woman’s X chromosomes has the hemophilia mutation, she has a backup and will avoid most of the symptoms. But if she passes ...