Patients with chronic obstructive pulmonary disease (COPD) may develop pulmonary hypertension because of pulmonary vasoconstriction secondary to alveolar hypoxia with additional vasoconstriction ...

Alveolar hypoxia causes pulmonary vasoconstriction by a variety of actions on endothelium and smooth muscle. This increased pulmonary vascular resistance can be further compounded by reactive ...

SaO 2 in hypoxia can be defended by increasing ventilatory drive; however, during heavy exercise, many athletes demonstrate limitations to expiratory flow and are unable to increase ventilation in ...

This is further supported by data showing that ischaemic preconditioning in the brain involves a hypoxia inducible factor-α-mediated increase in expression of the CYP2C11 epoxygenase enzyme in ...

I’ve rarely seen hypoxic training spoken or written about in fitness content, and it’s surprising. The technique was highly ...

"Your heart rate slows down, you have peripheral vasoconstriction where the blood ... There's been a lot of interest in understanding hypoxia adaptations - adaptations to low oxygen levels." ...

According to Prolong Pharmaceuticals, the investigational product is expected to reduce the effects of ischemia by preventing vasoconstriction and reducing inflammation, allowing for the delivery of ...

I am an Emeritus Professor of Health Services Research (2022-present) and was Dean of ScHARR (2010-2017). I was also the inaugural Director of the NIHR School for Public Health Research (2012-2017). I ...

James Larke graduated from the programme in 2017 and was awarded the prize for best student and for joint best dissertation. Evaluating the impact of difficulty kneeling after knee replacement on ...

After working in evidence synthesis, I have developed an extensive interest in translating research into clinical practice and evidence-based medicine. For the NIHR Advanced Fellowship, I would like ...

My overarching research focus is to understand how immune activation is linked to heart disease. Following a severe infection like pneumonia, individuals are at a higher risk of heart attack or stroke ...