A figure from the paper shows that an siRNA delivered by a lipid nanoparticle was able to reduce expression of the protein PU.1 and other related markers (IBA1, C1q, GFAP) in the brains of mice.

Two start-ups have launched to develop next-generation drugs using small interfering RNA (siRNA) to silence genes. The first, Judo Bio, is a spin-off of the venture capital firm Atlas Venture.

To overcome these barriers, many siRNA delivery systems have been developed. Among these, lipid-based nanoparticles have great potential owing to their biocompatibility and low toxicity in ...

In barely a decade, RNA-mediated interference (RNAi) has evolved from a fascinating biological phenomenon into a powerful experimental tool. Progress in genome sequencing and annotation, as well ...

Insitro has teamed up with Eli Lilly to help power programs into the clinic, tapping the Big Pharma for an option on technology to deliver siRNA molecules it discovered using its machine learning ...

Adds Kellie Sirna, principal designer and founder of Studio 11 Design, those in their 30s are foregoing the long-dominant ...

Welcome to the 3 rd Annual RNAi – Based Therapeutics Summit: Overcoming Barriers for Targeted siRNA Therapeutics Built with biopharmaceutical industry insights, this in person conference will ...

The following abstracts showcase the top cutting-edge research presented at the European Society for Medical Oncology (ESMO) ...

The company has designed a drug candidate that combines a ligand with small interfering RNA (siRNA) that should silence messenger RNA (mRNA) and, in turn, reduce certain solute carrier proteins ...

WVE-007 (INHBE GalNAc-siRNA for obesity) is on track to initiate a clinical trial in 1Q 2025; new preclinical data for WVE-007 demonstrate opportunit ...

The firm's technology platforms include antibody, T cell, innate immunity and siRNA, which are designed to stimulate and enhance the immune system by exploiting critical observations of natural ...

Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) today announced that it is scheduled to participate in the following upcoming events: ...