BMJ19h
POS0803 VUNAKIZUMAB IN ACTIVE ANKYLOSING SPONDYLITIS: A RANDOMIZED, DOUBLE-BLIND, ADAPTIVE, SEAMLESS, PHASE 2/3 STUDY
3 The First Affiliated Hospital of Guangxi Medical University, NanNing, China 4 The Second Affiliated Hospital of Guangxi Medical University, NanNing, China 5 The First Affiliated Hospital of ...
BMJ17h
AB0092 FIBRIN ADHESION IS A PANNUS-INDEPENDENT MECHANISM OF CARTILAGE DEGENERATION IN RHEUMATOID ARTHRITIS
Background: Current concepts of cartilage destruction in inflammatory arthritis include pannus infiltration by inflamed synovial tissue as well as direct detrimental effects of inflammatory cytokines ...
BMJ1d
Single-cell transcriptome analysis identifies skin-specific T-cell responses in systemic sclerosis
Objectives Although T cells have been implicated in the pathogenesis of systemic sclerosis (SSc), a comprehensive study of T-cell-mediated immune responses in the affected skin of patients with ...
BMJ10d
The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositis
Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Dr R G Cooper, Rheumatic Diseases Centre, Hope Hospital, Salford, M6 8HD, UK; ...
BMJ3d
Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade
Correspondence to Professor Ling Qin, Prince of Wales Hospital, Hong Kong, China; lingqin{at}cuhk.edu.hk; Professor Kingston King-lun Mak, Joint Center for Musculoskeletal Research, Guangzhou ...
BMJ11d
Use of multidimensional composite scores in rheumatology: parsimony versus subtlety
Rheumatic and musculoskeletal diseases (RMDs) form a diverse group of diseases. Proper disease assessment is pivotal, for instance to make treatment choices and for optimising outcome in general. RMDs ...
BMJ8d
Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7
Objectives To investigate the role of mechanical stress in cartilage ageing and identify the mechanistic association during osteoarthritis (OA) progression. Conclusions FBXW7 is a key factor in the ...
BMJ11d
Irritable bowel syndrome symptoms in axial spondyloarthritis more common than among healthy controls: is it an overlooked comorbidity?
Correspondence to Dr Johan Karlsson Wallman, Department of Rheumatology, Skåne University Hospital Lund, Lund 22185, Sweden; johan.81.karlsson{at}gmail.com We aimed to compare the prevalence of gut ...
BMJ9d
Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications
Objective Autoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of rheumatoid arthritis (RA). The ...
BMJ5d
B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trial
Objective Randomised trials of type I anti-CD20 antibodies rituximab and ocrelizumab failed to show benefit in proliferative lupus nephritis (LN). We compared obinutuzumab, a humanised type II ...
BMJ10d
Compendium of skin molecular signatures identifies key pathological features associated with fibrosis in systemic sclerosis
Correspondence to Dr Ki-Jo Kim, Division of Rheumatology, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, 93, Jungbu-daero, Paldal-gu, ...
BMJ3d
AB0132 AFIMETORAN (BMS-986256), AN EQUIPOTENT TLR7/8 ANTAGONIST, DEMONSTRATES STEROID-SPARING EFFECTS IN A LUPUS MOUSE MODEL
2 Biocon Bristol Myers Squibb Research Center, Discovery Biology, Bangalore, India 3 Bristol Myers Squibb, Medicinal Chemistry, Lawrenceville, United States of America 4 Bristol Myers Squibb, ...