it does provide the highest level of evidence for an individual research trial. Additionally, it is the only RCT found from the identified search strategies that involved naturally acquired ...

mean that regulators are sometimes forced to accept immature RCT evidence due to high levels of unmet medical need. As a result, health technology assessment (HTA) bodies have to make uncertain ...

Real-world evidence (RWE) must become a fundamental accompaniment to traditional RCT data in proving value, but uptake has been relatively slow and steady to date. As the drive towards data-driven ...