The 49ers have ruled out two key starters versus the Cardinals in the regular season finale. Deebo Samuel and Deommodore Lenoir will not be available for them. Their 2024 season is over with.

This is a long list of starters who could not practice for the 49ers on Wednesday in their first Week 18 session. Take a deep breath when reading the list aloud because it is exhausting.

The Detroit Lions probably didn’t have to play their starters on Monday night, but did, and the blueprint for the rest of their season became clearer. The Lions can score a lot of points.

The San Francisco 49ers 2024 season will come to a close in less than a week's time. The final game of this year's campaign will be played on the road against the Arizona Cardinals. However ...

While the 49ers have been dealing with injuries all season, they added a key player to the list in last week's loss to the Lions, as quarterback Brock Purdy hurt his right elbow in the closing ...

SANTA CLARA, Calif. -- For much of the season, San Francisco 49ers coach Kyle Shanahan has looked at backup quarterbacks Brandon Allen and Joshua Dobbs as dual No. 2s behind Brock Purdy.

The Arizona Cardinals host the San Francisco 49ers on Sunday at 4:25 p.m. ET, in a battle between a pair of excellent receivers in Trey McBride and George Kittle. The Cardinals are compiling 356.1 ...

The San Francisco 49ers (6-10) will be aiming to snap a three-game losing streak against the Arizona Cardinals (7-9). The Cardinals are the favorites, expected to win by at least a field goal but ...

When the NFL season began, few would have bet the Cardinals (7-9) would enter Week 18 of the season with a better record than the 49ers (6-10). Expected to be the top seed in the NFC playoffs, the ...

In terms of stakes, the game had limited meaning for both teams. For the Detroit Lions — who defeated the San Francisco 49ers 40-34 — Week 18’s game against the Minnesota Vikings will decide ...