NNRTIs bind to a hydrophobic pocket near the catalytic site of HIV-1 RT and inactivate enzymatic activity. NNRTI-resistance mutations & their mechanism of drug resistance The most prevalent NNRTI ...

The same mutation that confers HIV resistance to some Ashkenazi Jews also puts them at higher risk of dying from West Nile fever, which is more prevalent in Israel than in the north European ...

Genotypic testing is recommended as the preferred resistance testing method to guide therapy in antiretroviral-naive and antiretroviral-experienced persons. A major limitation of clinically ...

Some mutations occur in the parts of HIV which are targeted by anti-HIV medications. This can result in strains of HIV developing that are less easily controlled by the drugs. These HIV strains are ...

For the reports involving oral PrEP, genetic testing of the HIV acquired in all but one breakthrough case detected mutations associated with resistance to emtricitabine, tenofovir, or both. For ...

A significant breakthrough in treating the Human Immunodeficiency Virus (HIV) came recently with the US Federal Drug ...

He had been searching for years for genetic changes that conferred HIV resistance ... as if a person had naturally inherited the mutation. This discovery has not yet translated into new treatments.

Though the number of individuals detected to have this specific mutation is relatively low compared to the number of HIV patients worldwide ... evolution, drug resistance, and vaccine efficacy.

receiving stem cells carrying a genetic mutation (CCRΔ5/Δ32) which means they lack the CCR5 co-receptor used by HIV to get access to cells – effectively creating an HIV-resistant immune system.