PAH is a rare condition in children, but is often fatal if left untreated, and protocols for pediatric patients have not been ...

The pulmonary vasculature is the exclusive target of disease in PPH, although its pathogenesis remains ... PPH associated with pulmonary arterial hypertension include collagen vascular disease ...

AliveGen USA Inc. (AliveGen), a clinical stage biopharmaceutical company, announced today that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to ALG-801 for the ...

A Mendelian analysis supports the idea that hyperuricemia may be an important risk factor for pulmonary arterial hypertension ...

In patients with PAH, reducing peripheral serotonin using rodatristat ethyl negatively affects pulmonary hemodynamics and cardiac function.

Tectonic's lead asset, TX45, is a long-acting Fc-relaxin fusion protein to treat group 2 pulmonary hypertension. Read why I'm ...

Vitiligo, a skin condition causing depigmentation, may significantly increase the risk of serious cardiovascular events.

Titled “PI3K p85[alpha]/HIF-1[alpha] accelerates the development of pulmonary arterial hypertension by regulating fatty acid ... “Therefore, understanding the pathogenesis [disease development] of PAH ...

Treatment of PAH can be based on supportive therapy, which includes the use of anticoagulants to prevent the formation of blood clots, diuretics to reduce fluid overload resulting from heart failure, ...

In patients for whom mechanical support is considered as a bridge to recovery rather than transplant (postcardiotomy, post–heart transplant, post–LV assist device implantation, and less often in ...

Lung diseases such as ALI, asthma, pulmonary fibrosis, pulmonary hypertension, COPD ... ROS formation and endogenous antioxidant defense is important in inhibiting pathogenesis. The experimental ...