Objective Long-term glucocorticoid use in SLE may have significant side effects; however, glucocorticoid discontinuation is occasionally associated with disease flare-ups. Therefore, we evaluated the ...

Hemophagocytic lymphohistiocytosis (HLH) is a well-recognised complication of systemic lupus erythematosus (SLE). In one small case series, HLH was noted in approximately 5% of patients with lupus. 1 ...

Systemic lupus erythematosus (SLE) is associated with increased expression of genes regulated by Type I interferon (IFN) in 50–70% of patients. 1 Previous studies, including our own, have demonstrated ...

As a consequence of increased survival over the last decades, patients with systemic lupus erythematosus (SLE) and their partners have an increased wish for pregnancy. However, pregnancy in SLE is ...

Case 1: A 28-year-old Mestizo female with diffuse alveolar hemorrhage A 28-year-old Mestizo female was diagnosed with systemic lupus erythematosus (SLE) a year ago, based on fever, polyarthralgia/its, ...

A meta-analysis of the four relevant randomized clinical trials evaluating direct oral anticoagulants (DOACs) versus warfarin in thrombotic antiphospholipid syndrome (APS) showed a significant ...

Case 2: An Afro-Caribbean female with atypical chest pain An Afro-Caribbean female presented with neuropsychiatric lupus at the age of 28 years and was treated with intravenous cyclophosphamide. Her ...

Immune dysregulation in systemic lupus erythematosus (SLE) results in the autoimmune manifestations of SLE, but also leads to an impaired immune response to pathogens and vulnerability to infections ...

Despite advancements in lupus management over the past two decades, infection remains a significant cause of morbidity and mortality among patients with systemic lupus erythematosus (SLE). 1 2 Various ...

Systemic lupus erythematosus (SLE) is a heterogeneous disease characterised by abnormalities in cellular and humoral immunity. The clinical complexity of SLE patients also comprise dysregulation of ...

With its first description published in 1976 the bimodal mortality pattern in systemic lupus erythematosus (SLE) described early mortality as usually being due to lupus disease itself or infection, ...

Case 2: A 28-year-old female with relapsing lupus nephritis A young female, 28 years, received a diagnosis of systemic lupus erythematosus at the age of 11 years (in London, UK), it was characterized ...