Kyler Murray threw for 242 yards and four touchdowns, two to Greg Dortch, and the Arizona Cardinals beat the injury-depleted San Francisco 49ers 47-24.

The San Francisco 49ers played the final few minutes against the Detroit Lions in Week 17 without Brock Purdy. They didn’t only lose their third consecutive game, but also saw their star quarterback ...

Coach Kyle Shanahan offered an update on Purdy's injury on Tuesday, sharing that the quarterback has a right elbow bruise ...

Unfortunately, Brock Purdy suffered an injury that sidelined him during the final minutes of the game between the San ...

That was the theme of tonight's game between the 49ers and Lions. They combined for 74 points. Neither defense was good for ...

Another bad night for the San Francisco 49ers got worse late in their Monday night game vs. the Detroit Lions. Quarterback ...

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Check out our Lions vs. 49ers how-to-watch guide to learn when they play and what free live streams are available ahead of ...

Brock Purdy threw for a career-high 377 yards, but it wasn’t enough as the San Francisco 49ers lost to the Detroit Lions on ...

The Lions prevailed in a high-scoring "Monday Night Football" game against the 49ers, setting up a big Week 18 matchup against the Vikings.

Ahead of their game against the Detroit Lions, it’s time to release our San Francisco 49ers Week 17 predictions.

The 49ers are riding a tow game losing streak into Week 17. They are poised to increase it to three in their matchup with the ...