Think back to that basic biology class you took in high school. You probably learned about organelles, those little “organs” inside cells that form compartments with individual functions.

Membraneless organelles, also called biomolecular condensates, are changing how scientists think about protein chemistry, ...

Lipids Open the Door. Microglial cells treated with unlipidated (top) or lipidated (bottom) ApoE (yellow) along with fluorescently tagged Aβ (green). Lipidated ApoE was more readily internalized and ...

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has ...

The microglia, in turn, seem to benefit, revving up metabolism and phagocytosis. The liver protein ApoA-I was particularly good at bolstering the latter. Overall, the findings suggest that the brain’s ...

More information: Shane K. B. Taylor et al, The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans, Proceedings of the National ...

More information: Shubham Singh et al, PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes, Cell (2024). DOI: 10.1016/j.cell.2024.09.036 Journal ...

Researchers have discovered a previously unknown cell-protecting function of a protein ... MANF was present in structures known as lysosomes which are associated with lifespan and protein ...