Some gain-of-function phenotypes of mutant p53 may result from the loss of multiple functions rather than novel functions. This aggregation effect, alongside impaired tetramer formation ...
The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro. The ability of mutant p53 to bind ...
Hosted on MSN5mon
Engineered DNA 'warhead' targets a common cancer mutationMore information: Lingping Kong et al, An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer, Science Bulletin (2024). DOI: 10.1016/j.scib.2024.05.017 ...
They reported an RNA aptamer-based PROTAC degrader capable of targeting and degrading the p53-R175H mutant previously. However, the serum instability limits its clinical translation. In this study ...
Presentation Details: Title: CLSP-1025, a novel bispecific T cell engager targeting a p53 R175H mutant peptide presented by HLA-A*02:01 Presentation Type: Poster Abstract Number: 1061 Date and ...
P53 Overexpression and mutation seen in children >3 years and young adults; possible independent prognostic factor Less common in elderly patients EGFR/EGFRvIII Less common in pediatric patients ...
“Based on proof-of-concept data demonstrating the ability of rezatapopt to selectively reactivate p53 in locally advanced/metastatic solid tumor patients with a TP53 Y220C mutation, we believe that ...
Results that may be inaccessible to you are currently showing.
Hide inaccessible results
Feedback