Colchicine in Cardiovascular Disease: In-Depth Review
Dec 29, 2021 · For years, colchicine has been used as a safe and well-tolerated agent in diseases such as gout and familial Mediterranean fever. The widely available therapeutic has several anti-inflammatory effects, however, that have proven effective in a broad spectrum of cardiovascular diseases as well.
Colchicine in Patients with Chronic Coronary Disease
Aug 31, 2020 · Evidence from a recent trial has shown that the antiinflammatory effects of colchicine reduce the risk of cardiovascular events in patients with recent myocardial infarction, but evidence...
Therapeutic potential of colchicine in cardiovascular medicine: a ...
Jan 19, 2022 · Based on its unique efficacy as an anti-inflammatory agent, colchicine has been used in the therapy of cardiovascular diseases including coronary artery disease, atherosclerosis, recurrent...
Colchicine’s Role in Cardiovascular Disease Management
Mar 21, 2024 · Randomized clinical trials established low-dose colchicine as an effective treatment for pericarditis and atherosclerotic cardiovascular disease. The mechanisms through which colchicine exerts its beneficial anti-inflammatory and cardiovascular effects remain an area of vigorous investigation.
Colchicine and the Failing Heart: - JACC: Heart Failure
Patients with stable heart failure on appropriate medical therapy were randomized to receive colchicine (0.5 mg twice daily) or placebo for 6 months. The primary endpoint of the study, for which the trial was powered adequately, was the proportion of patients achieving at least a 1-grade improvement in New York Heart Association functional class.
What’s Old is New Again – A Review of the Current Evidence of ...
In a hamster model of congestive heart failure, colchicine was shown to reduce myocardial cell stiffness . There was one RCT conducted by Deftereos to evaluate the efficacy of colchicine in patients with chronic stable heart failure . No benefit in terms of improvement in functional class, echographical measurements, or mortality was ...
Colchicine efficacy and safety for the treatment of cardiovascular ...
Colchicine proved effective in the reduction of adverse CO across different clinical settings (Fig. 1), although in the single RCT performed in the setting of heart failure showed neutral effects (10.7% vs. 13.7%, RR 0.78, 95% CI 0.42–1.48, p = 0.45).
Colchicine and the Failing Heart: A FINER Anti-Inflammatory Agent?
Patients with stable heart failure on appropriate medical therapy were randomized to receive colchicine (0.5mg twice daily) or placebo for six months.
Colchicine and the heart | European Heart Journal - Oxford …
May 7, 2021 · The involvement of inflammatory pathways in the pro-fibrotic process associated with adverse ventricular remodelling following myocardial infarction has led to trials aimed at assessing whether inhibiting inflammation with colchicine can …
Colchicine in acutely decompensated heart failure: the COLICA trial
Colchicine was safe and effective in reducing inflammation in patients with AHF, however colchicine and placebo exhibited comparable effects on reducing NT-proBNP and preventing new worsening heart failure events.