PEG-fibrinogen hydrogel microspheres as a scaffold for …
Aug 9, 2022 · Here we studied ex vivo a novel topical delivery system of encapsulated cells in hybrid polyethylene glycol-fibrinogen (PEG-Fb) hydrogel microspheres to respiratory tract models. We investigated basic parameters of cell encapsulation, delivery and release in conditions of inflamed and damaged lungs of bacterial-infected mice.
Cell encapsulation utilizing PEG-fibrinogen hydrogel supports …
Feb 21, 2018 · Here, we utilized a uniquely fabricated semi-synthetic 3D polyethylene glycol-fibrinogen (PEG-Fb) hydrogel scaffold, which exhibits both high stability and high bioactivity, to encapsulate HEK293 cells for the production of human …
A three-dimensional spheroidal cancer model based on PEG …
Jan 1, 2017 · The presence of PEGDA renders PEG-Fb photocrosslinkable at physiological temperature and pH and provides sustained mechanical stiffness and architecture to the 3D matrix. Fibrinogen facilitates critical integrin-mediated signaling mechanisms required for cell attachment, spreading, and proliferation [23] .
Structure of an anti-PEG antibody reveals an open ring that …
Sep 8, 2020 · The structure reveals an open ring-like sub-structure in the Fab paratope, whereby PEG backbone is captured and then stabilized via Van der Waals interactions along the interior and...
Understanding (PEG) and synthetic PEG derivatives - News-Medical.net
Jan 10, 2024 · This article from Merck outlines poly(ethylene glycol) (PEG) and synthetic PEG derivatives and how they're used for tissue engineering and cell delivery.
Review PEGylation of Biopharmaceuticals: A Review of
Feb 1, 2016 · A trend toward the use of complex PEG architectures and larger PEG polymers, but with very pure and well-characterized PEG reagents is described. Nonclinical toxicology findings related to PEG in approved PEGylated biopharmaceuticals are summarized.
Structural basis of polyethylene glycol recognition by antibody
Jan 7, 2020 · Because the underlying mechanism for specific PEG binding has not been elucidated, by solving complex crystal structures of the anti-PEG Fab with PEG and by analyzing their interactions, we provide a possible basis for designing improved anti …
PEG Linkers: Structure, Applications & Contributions - Creative …
Polyethylene glycol (PEG) is a synthetic, water-soluble polymer composed of repeating units of ethylene oxide. It is widely known for its biocompatibility and non-toxic nature, which makes it suitable for use in various medical and pharmaceutical applications.
PEGylated Lipid Nanoparticle Formulations: Immunological Safety …
PEGylation (covalently binding PEG to a compound) was initially invented to facilitate protein drugs in avoiding immune response (3,7,8) but was later discovered to be also quite efficient at enhancing the surface properties of the LNPs by blocking access to their surface through steric obstruction, thus reducing opsonization by blood proteins a...
Polyethylene Glycol (PEG) and PEGylation of Proteins
Polyethylene glycol is a biologically inert, non-immunogenic chemical that confers greater water solubility to proteins, labeling tags and crosslinkers with which it is incorporated as constituent chemical group. This page provides a brief introduction to the use and types of PEG reagents available to protein biology researchers.