Dec 16, 2024 · This cover highlights the article ZBTB48 is a priming factor regulating B-cell-specific CIITA expression by Grishma Rane, Dennis Kappei and colleagues. The study identifies how ZBTB48, represented as pangolins, binds to two distinct binding sites at the B-cell-specific promoter of CIITA, the master regulator of the MHC-II immune gene expression program, to …