Cell encapsulation utilizing PEG-fibrinogen hydrogel supports …
WEBFeb 21, 2018 · Here, we utilized a uniquely fabricated semi-synthetic 3D polyethylene glycol-fibrinogen (PEG-Fb) hydrogel scaffold, which exhibits both high stability and high bioactivity, to encapsulate HEK293 cells for the production of human recombinant acetylcholine esterase (AChE).
PEG-fibrinogen hydrogel microspheres as a scaffold for …
WEBAug 9, 2022 · Here we studied ex vivo a novel topical delivery system of encapsulated cells in hybrid polyethylene glycol-fibrinogen (PEG-Fb) hydrogel microspheres to respiratory tract models. We investigated basic parameters of cell encapsulation, delivery and release in conditions of inflamed and damaged lungs of bacterial-infected mice.
Understanding (PEG) and synthetic PEG derivatives - News-Medical.net
WEBJan 10, 2024 · Poly (ethylene glycol) (PEG) is the most extensively studied synthetic polymer for tissue engineering. PEG provides benefits, including a hydrated structure, which typically leads to high...
Polyethylene glycol - Wikipedia
WEBThe structure of PEG is commonly expressed as H− (O−CH 2 −CH 2) n −OH. [3] Uses. Medical uses. Pharmaceutical-grade PEG is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms. [4] PEG is the basis of a number of laxatives (as MiraLax, RestoraLAX, etc.). [5] .
All-Atom Molecular Dynamics Simulations of Polyethylene Glycol (PEG …
WEBApr 27, 2022 · Here, we report a crystal structure illustrating the structural properties and conformation of the APA 6-3 Fab bound to the backbone of PEG. The structure reveals an open ring-like sub-structure in the Fab paratope, whereby PEG backbone is captured and then stabilized via Van der Waals interactions along the interior and exterior of the ring ...
Structure and Intermolecular Interactions in Aqueous Solutions of ...
WEBApr 15, 2022 · The purpose of the present work was to study the structure and interaction of PEG molecules in an aqueous medium in a wide range of concentrations and molecular weights and provide a reference that can be further used in structural studies of PEG-containing systems.
The Mechanism of Polyethylene Glycol-Induced Fusion in Model …
WEBPEG is a water-soluble fusogen unlike nonpolar or amphipathic chemical fusogens, such as fatty acids, retinol, and lysolecithin, that act by entering the bilayer. Thus, it is relatively easy to remove PEG from the cell medium by washing.
Uniform poly(ethylene glycol): a comparative study
WEBOct 18, 2019 · Poly (ethylene glycol) (PEG) is a biocompatible, flexible, and hydrophilic polymer that is widely applied in numerous fields. Especially in pharmaceutical research, PEG is used as a...
PEG Linkers: Structure, Applications & Contributions - Creative …
WEBPolyethylene glycol (PEG) is a synthetic, water-soluble polymer composed of repeating units of ethylene oxide. It is widely known for its biocompatibility and non-toxic nature, which makes it suitable for use in various medical and pharmaceutical applications.
Polyethylene Glycol (PEG) Selection Guide - Aladdin Sci
WEBPolymer Architecture. 1，Linear PEGs are commonly used for PEGylation, bioconjugation, and crosslinking. 2，Multi-arm PEGs (4-,6-,8-arm) can be crosslinked into hydrogels and scaffolds for drug delivery or tissue engineering. 3，Y-shaped PEGs are typically used for PEGylation, as the branched structure may improve stability in vivo. Reactivity.