Factor XIII - Wikipedia
Factor XIII is a transglutaminase that circulates in human blood as a heterotetramer of two A and two B subunits. Factor XIII binds to the clot via their B units. In the presence of fibrins, …
Factor XIII Deficiency - StatPearls - NCBI Bookshelf
Feb 12, 2024 · Factor XIII (FXIII) deficiency is a rare bleeding disorder that presents with symptoms spanning from delayed umbilical cord separation to intracranial hemorrhage. In its …
Physiology, Factor XIII - StatPearls - NCBI Bookshelf
Nov 5, 2023 · Factor XIII, also referred to as fibrin stabilizing factor, plays a crucial role in the coagulation cascade by enhancing the stability of blood clot formation. The plasma form of …
Factor XIII Deficiency - Symptoms, Causes, Treatment | NORD
Apr 27, 2022 · Factor XIII deficiency is a rare, genetic bleeding disorder characterized by deficiency of clotting factor XIII. Clotting factors are specialized proteins that are essential for …
Factor XIII Deficiency | Symptoms, Genetics, Treatment | NBDF
An overview of symptoms, genetics, and treatments to help you understand factor XIII deficiency. Factor XIII (FXIII), or fibrin stabilizing factor, deficiency was first reported in the literature in …
Factor XIII deficiency - Wikipedia
Deficiency of Factor XIII leads to defective cross-linking of fibrin and vulnerability to late re-bleeds when the primary hemostatic plug is overwhelmed. Bleeding tendencies similar to …
Factor XIII deficiency - MedlinePlus
Factor XIII deficiency is a rare bleeding disorder. Researchers have identified an inherited form and a less severe form that is acquired during a person's lifetime. Signs and symptoms of …
Factor XIII-A: An Indispensable “Factor” in Haemostasis and …
Factor XIII (FXIII) is a transglutaminase enzyme that catalyses the formation of ε- (γ-glutamyl)lysyl isopeptide bonds into protein substrates. The plasma form, FXIIIA 2 B 2, has an established …
FXIII Deficiency - Rare Coagulation Disorders
Factor XIII (FXIII) was first identified by Laki and Lorand in 1948, when they surmised and then confirmed, the presence of a clotting factor whose major role was to stabilize and strengthen …
Factor XIII: A Coagulation Factor With Multiple Plasmatic and …
FXIII is a pro-TG that circulates in plasma in tetrameric form (FXIII-A 2 B 2) (124, 259, 263). It consists of two potentially active, catalytic A subunits (FXIII-A) and two carrier/inhibitory B …
Factor XIII Deficiency - Haemnet
Factor XIII (FXIII) is one of several clotting factors that are components of the coagulation cascade (Figure 1). This complex sequence of step-wise interactions is initiated in response to …
Factor XIII - Bleeding & Clotting Disorders Institute
Factor XIII is the protein responsible for stabilizing the formation of a blood clot. In the absence of Factor XIII, a clot will still develop but it will remain unstable. When someone has a deficiency …
Physiology of Factor XIII: Understanding its Role in Blood Clot ...
Aug 12, 2023 · Explore the physiology of Factor XIII and its role in blood clot formation and wound healing. Learn about its structure, activation, functions in stabilizing fibrin clots, and …
Factor XIII Deficiency - PubMed
Feb 12, 2024 · Factor XIII (FXIII) deficiency is a rare bleeding disorder that presents with symptoms spanning from delayed umbilical cord separation to intracranial hemorrhage. In its …
Factor XIII Deficiency? The symptoms of FXIII Deficiency may depend (but not always) upon how much FXIII you have circulating in your blood or how well it functions. Normal FXIII activity …
Factor XIII Uses, Side Effects & Warnings - Drugs.com
Jan 29, 2024 · Factor XIII (thirteen) is a naturally occurring protein in the blood that helps blood to clot. A lack of clotting factors can cause uncontrolled bleeding, as the blood is unable to clot …
Factor XIII Deficiency Information & Resources | CSL
What is Factor XIII Deficiency? Factor XIII deficiency is a rare inherited bleeding disorder in which Factor XIII, the protein in the blood responsible to help stabilize a blood clot, is malfunctioning …
Physiology, Factor XIII | Treatment & Management | Point of Care
Nov 5, 2023 · Factor XIII, also referred to as fibrin stabilizing factor, plays a crucial role in the coagulation cascade by enhancing the stability of blood clot formation. The plasma form of …
Acquired Factor XIII Deficiency Inducing Recurrent and Fatal …
Factor XIII is a zymogen which, after activation in factor XIIIa, is able to stabilise the fibrin and therefore the clot. 1 Its inherited deficiency is relatively rare but clinical manifestations may be …
Factor XIII Deficiency - Medscape
Mar 18, 2017 · FXIII deficiency, an autosomal recessive disorder, is a rare but potentially life-threatening cause of a hemorrhagic diathesis. Paradoxically, alterations in FXIII may also …
Factor XIII Deficiency - Hematology/Oncology Clinics
Oct 1, 2021 · Factor XIII (FXIII) deficiency is a rare autosomal recessive disorder that can result in life-threatening bleeding and early fetal loss. FXIII not only is responsible for cross-linking …