About - eLife
eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science.
Latest research | eLife
Oct 29, 2024 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in …
How to measure and evaluate binding affinities | eLife
Aug 6, 2020 · Quantitative measurements of biomolecule associations are central to biological understanding and are needed to build and test predictive and mechanistic models. Given the advances in high-throughput technologies and the projected increase in the availability of binding data, we found it especially timely to evaluate the current standards for ...
Reliable protein-protein docking with AlphaFold, Rosetta, and …
Feb 9, 2024 · In this work, we combine the features of a top deep learning approach (AlphaFold-multimer 4) with physics-based docking schemes (ReplicaDock 2.0 2) to systematically dock protein interfaces. The overarching goal is to create a robust pipeline for easier, reproducible, and accurate modeling of protein complexes.
Publishing and peer review at eLife · eLife
2 Peer review. eLife editors - who are all active researchers - discuss new submissions and decide which will be peer reviewed. The criteria used by the editors are discussed in “How and why eLife selects papers for peer review”.. Each peer reviewer is asked to write a Public Review of the article, and to recommend ways in which the authors could improve it.
Magazine - eLife
Oct 25, 2024 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in …
Development: Investigating the origin of insect metamorphosis
Dec 21, 2023 · Given Darwin’s longstanding interest in entomology, it is possible he had insects and metamorphosis in mind when he wrote about “endless forms most beautiful” in the final sentence of On the Origin of Species.More than half of the 2.2 million animal species that have been described are insects, and 98% of these undergo some form of metamorphosis during …
Open Knowledge Maps: A visual interface to the world’s ... - eLife
Feb 26, 2020 · Introduction. Open Knowledge Maps is a charitable, non-profit organization dedicated to dramatically increasing the visibility of scientific knowledge for science and society alike. Headquartered in Vienna, Austria, Open Knowledge Maps comprises an international community including team and supporting members, advisors and partner organizations.
Female fertility and the zona pellucida - eLife
Jan 25, 2022 · The zona pellucida (ZP) is a relatively thick extracellular matrix (ECM) that surrounds all mammalian oocytes, eggs, and preimplantation embryos, from monotremes that lay eggs to placental mammals (Wassarman and Litscher, 2016; Wassarman and Litscher, 2021).During oogenesis, small nongrowing oocytes that lack a ZP undergo tremendous growth …
Lung evolution in vertebrates and the water-to-land transition
Jul 26, 2022 · All life on Earth started out under water. However, around 400 million years ago some vertebrates, such as fish, started developing limbs and other characteristics that allowed them to explore life on land. One of the most pivotal features to evolve was the lungs, which gave vertebrates the ability to breathe above water. Most land-living vertebrates, including humans, …