HDBuzz - Huntington’s disease research news.
4 days ago · Beta-blockers associated with delayed onset and decreased progression of Huntington’s disease. A well-studied, widely used class of drugs for heart health may have benefits for Huntington’s disease.
2024: Year in Review - HDBuzz - Huntington’s disease research news.
4 days ago · As we wave goodbye to 2024, the HDBuzz team reflects on a year marked by significant progress, challenges, and hope. From breakthroughs at the lab bench, advancements in drug development, and both road bumps and triumphs in clinical trials, we have gained new insights into the workings of Huntington’s disease (HD), and made great strides towards finding medicines which might slow or halt ...
Moving into the Fast Lane: uniQure and the FDA Are on the Same …
On December 10, 2024 we received a regulatory update from uniQure about their drug, AMT-130, that they’re advancing through the clinic for Huntington’s disease (HD). On the call, uniQure announced alignment with the FDA on key elements to …
Beta-blockers associated with delayed onset and decreased …
Dec 16, 2024 · Research led by Dr. Peg Nopoulos from the University of Iowa used the Enroll-HD database to answer a key question: “How does beta-blocker use influence motor-diagnosis onset and progression rates in premanifest and early motor-manifest Huntington’s disease (HD)?”.They found beta-blocker use was associated with positive effects!
Interruptions are encouraged - HDBuzz - Huntington’s disease …
Oct 14, 2024 · A CRISPR-based approach called “base editing” is being explored to develop a new potential treatment for Huntington's disease. Editing a single letter in the genetic code with base editing may be the key for delaying HD symptoms, maybe by a decade.
Interim update from Vico Therapeutics on their CAG-targeting …
Dec 9, 2024 · Vico Therapeutics recently presented at several conferences to share an interim update on their Phase 1/2a clinical trial testing their drug called VO659, which targets the repeating C-A-Gs in people with Huntington’s disease (HD). These data suggest that VO659 may be able to reduce levels of the toxic HD protein in the small group of participants tested so far and gives insights into safety.
Huntington's Disease Therapeutics Conference 2024 - Day 3
Mar 7, 2024 · Glossary; huntingtin protein The protein produced by the HD gene.; clinical trial Very carefully planned experiments designed to answer specific questions about how a drug affects human beings ; therapeutics treatments ; juvenile HD Huntington's disease where symptoms begin before the age of 20.; CAG repeat The stretch of DNA at the beginning of the HD gene, which contains the sequence CAG ...
2024 HDBuzz Prize: Beyond nerve cells – who are the other players …
Nov 25, 2024 · We're proud to announce Jenny Lange as a 2024 HDBuzz Prize winner! Our brains are made up of many types of cells that play different roles in the changes caused by HD. This study dives into a star-shaped cell called astrocytes and their role in HD.
Start here! - HDBuzz - Huntington’s disease research news.
Nov 1, 2012 · Welcome to HDBuzz! This special page is for people who are new to Huntington’s disease, or new to the world of HD research. Reading the articles linked here will help you pick up the basics of what Huntington’s disease is, and get up to speed with some of the most promising things scientists are doing to come up with effective treatments for HD.
HDBuzz - Huntington’s disease research news.
Mini brains grown in a dish shed light on Huntington’s disease and how we might treat it. Exciting new findings using 3D human lab-grown mini brains inform ongoing HTT-lowering trials and suggest that stem cell transplants for HD may improve cell-to-cell communication and reduce disease features.