A Leptin Receptor Antagonist Attenuates Adipose Tissue Browning …
Jul 31, 2021 · The pegylated leptin receptor antagonist (PLA) binds to but does not activate the leptin receptor. We tested the efficacy of this PLA in Ctns−/− mice. We treated 12-month-old Ctns−/− mice and control mice with PLA (7 mg/kg/day, IP) or saline as a vehicle for 28 days.
Abstract: Mice lacking the functional cystinosin gene (Ctns /), a model of infantile nephropathic cystinosis (INC), exhibit the cachexia phenotype with adipose tissue browning and muscle wasting. Elevated leptin signaling is an important cause of …
A Leptin Receptor Antagonist Attenuates Adipose Tissue ... - PubMed
Jul 31, 2021 · The pegylated leptin receptor antagonist (PLA) binds to but does not activate the leptin receptor. We tested the efficacy of this PLA in Ctns-/- mice. We treated 12-month-old Ctns-/- mice and control mice with PLA (7 mg/kg/day, IP) or saline as a vehicle for 28 days.
Journal of Cachexia, Sarcopenia and Muscle - Wiley Online Library
Aug 29, 2024 · The effects of PLA on serum leptin levels were not observed in Ctns −/− mice. PLA treatment improved bone disease in Ctns −/− mice. Whole-body weight/BMC/BMD were significantly increased in PLA-injected Ctns −/− mice as compared with Ctns −/− mice treated with vehicle (Figure 3).
Leptin signalling altered in infantile nephropathic cystinosis …
PLA or AgRP treatment attenuated femur STAT3 content in Ctns-/-mice. Conclusions: Our findings suggest a significant role for dysregulated leptin signalling in INC-related bone disorder, either directly or potentially involving a muscle-bone interplay.
A Leptin Receptor Antagonist Attenuates Adipose Tissue Browning …
Jul 31, 2021 · Mice lacking the functional cystinosin gene (Ctns−/−), a model of infantile nephropathic cystinosis (INC), exhibit the cachexia phenotype with adipose tissue browning and muscle wasting....
PLA attenuates cachexia in Ctns −/− mice. We have performed …
Ctns −/− and WT mice were given PLA (7 mg/kg/day, IP) or vehicle (normal saline), respectively. The study period was 28 days and all mice were fed ad libitum.
PLA attenuates adipose tissue browning in Ctns −/− mice. Gene ...
Download scientific diagram | PLA attenuates adipose tissue browning in Ctns −/− mice. Gene expression of beige adipocyte markers (CD137, Tbx-1 and Tmem26) in inguinal WAT was measured by qPCR.
Cystinosis - GeneReviews® - NCBI Bookshelf
Mar 22, 2001 · Clinical Description. The three types of cystinosis ‒ nephropathic (classic renal and systemic disease), intermediate (a late-onset variant of nephropathic cystinosis), and non-nephropathic (ocular) ‒ are allelic disorders caused by pathogenic variants in CTNS.
receptor antagonists (PLA) bind to leptin receptors without activating them. Professor Arieh Gertler prepared and pro-vided the PLA.12 Twelve-month-old male Ctns / mice and WT mice were given PLA (7 mg/kg/day, IP) or vehicle (normal saline) for 28 days. We used a pair-feeding strategy. Vehicle injected Ctns / mice were fed ad libitum. Dietary ...
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