T-box transcription factor T - Wikipedia
Tbxt is the founding member of the T-box family which in mammals currently consists of 18 T-box genes. The crystal structure of the human brachyury protein was solved in 2017 by Opher Gileadi and colleagues at the Structural Genomics Consortium in Oxford.
On the genetic basis of tail-loss evolution in humans and apes
Feb 28, 2024 · When we engineered the mouse Tbxt gene with the human TBXT gene structure by inserting the AluSx1–AluY pair—as well as Alu-independent inverted RCSs in a separate mouse ES cell line—we ...
How Humans Lost Their Tails - Scientific American
Feb 28, 2024 · When AluY jumped into a gene called TBXT, the insertion seemed to result in tail loss in apes—including human ancestors. (TBXT is responsible for making a protein that is important to the...
‘Jumping gene’ may have erased tails in humans and other
Sep 21, 2021 · But humans and our cousins the great apes lack them. Now, researchers may have unearthed a simple genetic change that led to our abbreviated back end: an itinerant piece of DNA that leapt into a new chromosomal home and changed how great apes make a key developmental protein.
We finally know why humans don't have tails | Live Science
Feb 28, 2024 · Approximately 25 million years ago, an ancestor of both humans and apes genetically diverged from monkeys and lost its tail. No one had identified the genetic mutation responsible for this...
TBXT T-box transcription factor T [ (human)] - National Center for ...
TBXT T-box transcription factor T [ (human)] Gene ID: 6862, updated on 2-Nov-2024. Summary. The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site.
Research identifies genetic change associated with human tail loss
Feb 28, 2024 · It found an insertion of DNA shared by apes and humans but missing in monkeys. When the research team engineered a series of mice to examine whether the insertion, in a gene called TBXT,...
How humans lost their tails — and why the discovery took 2.5
Feb 28, 2024 · In 1927, Ukrainian scientist Nadine Dobrovolskaya-Zavadskaya described a strain of short-tailed lab mouse that, she proposed, carried a mutation in a gene called T, the human equivalent of...
A mobile DNA sequence could explain tail loss in humans and …
Feb 28, 2024 · In humans, the tail disappears at the end of the embryonic phase — approximately eight weeks in utero 2 — although internal parts remain in the form of the tailbone. The loss of the tail is...
TBXT T-box transcription factor T [ Homo sapiens (human) ]
Sep 18, 2024 · The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for …