Polyethylene glycol - Wikipedia
Polyethylene glycol (PEG; / ˌpɒliˈɛθəlˌiːnˈɡlaɪˌkɒl, - ˈɛθɪl -, - ˌkɔːl /) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), …
PEGylated Lipid Nanoparticle Formulations: Immunological Safety …
As one of their key constituents, polyethylene glycol (PEG)–lipid conjugates are important in defining LNP physicochemical characteristics and biological activity. PEGylation has proven particularly efficient in conferring longer systemic circulation of LNPs, thus greatly improving their pharmacokinetics and efficiency.
PEG-Lipids: Quantitative Study of Unimers and Aggregates …
Jul 7, 2023 · Here, we study the dynamics of poly(ethylene glycol)-lipid (PEG-Lipid) conjugates aiming at a better understanding of their molecular properties and aggregation behavior in solution. Those PEG-Lipids are used as components of lipid nanoparticles (LNPs).
The role of lipid components in lipid nanoparticles for vaccines …
Sep 1, 2022 · PEG-lipids stabilize LNPs during preparation and storage by providing a steric barrier that both drives self-assembly and prevents aggregation. Further, the type of PEG-lipid partly controls LNP circulation time and cellular interactions.
Lipid nanoparticles for mRNA delivery | Nature Reviews Materials
Aug 10, 2021 · Lipid nanoparticle–siRNA formulations containing PEG 2000-DMG have shorter circulation times and higher delivery efficacy in vivo than formulations containing PEG 2000-DSG 129.
Polyethylene glycol (PEG)-associated immune responses ... - Nature
Nov 2, 2023 · Lipid nanoparticles (LNP) composed of ionizable cationic lipid, cholesterol, 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and polyethylene glycol (PEG)-conjugated lipid, have...
Pegylated Lipid - an overview | ScienceDirect Topics
Dipalmitoyl phosphatidylcholine (DPPC), distearoyl phosphatidylethanolamine-polyethylene glycol 2000 (DSPE-PEG2000), and cholesterol are the lipids of choice for PEGylated lipid nanoparticles. PEGylated SLN are prepared by emulsification and can be purified by ultracentrifugation.
PEG-lipid micelles as drug carriers: physiochemical attributes ...
PEG-lipid micelles, primarily conjugates of polyethylene glycol (PEG) and distearyl phosphatidylethanolamine (DSPE) or PEG-DSPE, have emerged as promising drug-delivery carriers to address the shortcomings associated with new molecular entities with suboptimal biopharmaceutical attributes.
What are PEG Lipids? - BOC Sciences
PEG Lipids represent a versatile class of amphipathic molecules with unique properties that make them valuable tools in the fields of drug delivery, imaging, diagnostics, and biotechnology.
Role of size, surface charge, and PEGylated lipids of lipid ...
Sep 11, 2024 · PEGylated lipids contribute to the evasion of macrophage capture, thereby enhancing nanoparticle stability and prolonging their efficacy in vivo [25, 26]. The presence of PEGylated lipids in LNPs extends their circulation time in vivo, which is particularly advantageous for intravenous injection [1, 27].