Stem cells: What they are and what they do - Mayo Clinic
Mar 23, 2024 · Request Appointment. Stem cells: What they are and what they do. Products and services. Stem cells: What they are and what they do. Stem cells offer promise for new medical treatments. Learn about stem cell types, current and possible uses, and the state of research and practice. By Mayo Clinic Staff. Stem cells: What they are and what they do.
Stem Cell Gene Therapy - an overview | ScienceDirect Topics
Stem cell-based gene therapy is a novel technology that maximizes the therapeutic effects of stem cells by engineering them to express therapeutic genes specific to the pathophysiology of the target disorder.
Current state of stem cell-based therapies: an overview - PMC
Stem cell-based therapies are defined as any treatment for a disease or a medical condition that fundamentally involves the use of any type of viable human stem cells including embryonic stem cells (ESCs), iPSCs and adult stem cells for autologous and allogeneic therapies (8).
Gene therapy - Mayo Clinic
Apr 23, 2024 · Stem cells. All cells in your body are created from stem cells. For gene therapy, stem cells can be altered or corrected in a lab to become cells to fight disease. Liposomes. These particles can carry the new, therapeutic genes to the target cells and pass the …
Stem cell-based therapy for human diseases | Signal ... - Nature
Aug 6, 2022 · Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), has recently emerged as a key player in regenerative medicine. hPSCs are...
Next-generation stem cells — ushering in a new era of cell-based ...
Apr 6, 2020 · Multipotent somatic stem cells, such as haematopoietic stem cells (HSCs), mesenchymal stem/stromal cells (MSCs) and fetal tissue-derived stem cells, give rise to tissue-restricted or...
Gene therapy: advances, challenges and perspectives - PMC
In gene therapy, a normal gene is inserted into the genome to replace an abnormal gene responsible for causing a certain disease. Of the various challenges involved in the process, one of the most significant is the difficulty in releasing the gene into the stem cell.
Successes and challenges in clinical gene therapy | Gene Therapy …
Nov 8, 2023 · Hematopoietic stem cell gene therapy (HSCGT) for inherited blood disorders uses the patient’s own (autologous) HSC that are gene corrected either by adding a normal copy of the...
Induced Pluripotent Stem Cells (iPSCs) and Gene Therapy: A …
While classical gene therapy mainly uses viral vectors to transfer genes, stem cell replacement gene therapy uses advanced methods such as CRISPR-Cas9 to correct genes and later introduce engineered iPSCs in patients.
Stem Cells in the Treatment of Disease | NEJM
May 1, 2019 · Figure 1. Types of Stem Cells. Tissue-specific “adult” stem cells that are capable of both self-renewal and specialized tissue repair reside in certain tissues, such as the epidermis, limbal...